STRIDE: EXPERIMENTAL AND STATISTICAL DESIGN CONSIDERATIONS

hydrochlorothiazide detection in urine samples by hplc-dad and experimental design dispersive l-l microextraction

hydrochlorothiazide (hct) is a diuretic agent which is shown to be effective in the treatment of hypertension. literature reports have demonstrated that urinary excretion data may be used to assess the bioavailability of various formulations containing this thiazide. also hct consumption by the athletes is one of the drugs which should be regulated by world anti-doping agency (wada), because of...

Experimental design considerations in microbiota/inflammation studies

There is now convincing evidence that many inflammatory diseases are precipitated, or at least exacerbated, by unfavourable interactions of the host with the resident microbiota. The role of gut microbiota in the genesis and progression of diseases such as inflammatory bowel disease, obesity, metabolic syndrome and diabetes have been studied both in human and in animal, mainly rodent, models of...

Microarray experiments: considerations for experimental design

Introduction Initially conceived and launched ten years ago, microarray technology has become an attractive choice for researchers to screen the expression of thousands of genes simultaneously. During its short history, the technology has made invaluable contributions to various scientific fields. One example is evident in human cancer research and the development of a prognostic tool based on ...

Reporting on Experimental Design and Statistical Analysis.

Introduction All of us in experimental science are concerned with scientific rigor and most journals have a policy on statistical analysis and data representation to ensure that issues of experimental design can be reviewed thoroughly. The policy at the Journal of Neuroscience is to require full reporting of statistical analyses and we ask our reviewers to report on the adequacy of those analys...

Introduction Experimental design and Statistical Parametric Mapping